Macrene Actives

"If we can stimulate our DNA repair molecules, we can at any age restore our skin to optimal health and protect the skin from the damage that causes skin aging and cancer."

— Dr. Macrene

Inspired by decades of Nobel Prize-winning DNA repair research, Dr. Macrene Alexiades developed MA37® Patented Technology to help optimize the delivery of high-performance actives that support visible skin rejuvenation.

Experience MA37® technology in High Performance Face Cream, High Performance Face Serum, and High Performance Tinted Moisturizer.

Join Dr. Macrene at Violet Grey East Hampton on August 7–8 for a personalized one-on-one consultation.

Receive a customized skin analysis, discuss your unique skin concerns and goals, and discover the science behind healthier-looking skin.

Appointments are limited and available by reservation only.

Reserve your spot through the link in today's Stories

Coming Soon! High Performance Broad Spectrum Mineral SPF 50

High Performance Broad Spectrum. Mineral SPF 50 combines broad-spectrum UV protection with clinically advanced skincare in a 100% mineral, lightweight, fragrance-free formula.

Powered by 30 active botanicals, it helps visibly firm, brighten, hydrate, and support the skin barrier while providing antioxidant defense against UV-induced oxidative stress.

Our Broad Spectrum SPF 50 formula helps protect against sunburn and early skin aging when used as directed. Regular use decreases the risk of skin cancer and early skin aging caused by the sun.

Follow along as we share more about High Performance Broad Spectrum Mineral SPF 50 in the weeks ahead.

"I'm focusing 1 million percent of my attention on hands."
— Dr. Macrene

Recently featured in Vanity Fair's "So You Got a Face Lift. What Are You Gonna Do About Your Hands?" article, Dr. Macrene discusses why the hands are often one of the first places to reveal visible signs of aging—and why they deserve the same attention as the face.

In the feature, she shares how fillers, PRF, and laser treatments can help restore a more youthful appearance to this often-overlooked area.

Thank you to Vanity Fair for highlighting this important conversation.

Dr. Macrene believes complexion products should improve skin—not simply cover it.

That's why High Performance Tinted Moisturizer was formulated with clinically advanced skincare actives alongside complexion-enhancing mineral pigments.

Available in six shades, the skin tone-adjusting formula features reflective properties and best-in-class luxury pigments that adapt to a broad range of skin tones.

Peptides, hyaluronic acids, and proline help improve the appearance of fine lines and wrinkles. Glucosamine and amino acids help visibly brighten uneven skin tone. Coffee seed extract, feverfew, and antioxidant-rich botanicals help calm the appearance of redness while defending against environmental stressors.

Developed by a dermatologist. Formulated by a scientist. Designed to support healthier-looking skin with every application.

A lovely mention to start the month.

We’re honored to see our High Performance Cleanser included in Fashionista’s June Beauty Favorites.

What makes this especially meaningful is that cleansing is often treated as a simple first step — but in Dr. Macrene’s philosophy, every step of skincare matters. A cleanser should leave skin feeling clean, balanced, and comfortable, never stripped.

That’s exactly why this formula was developed with a pH-conscious approach, gentle plant-based surfactants, antioxidants, emollients, and niacinamide to support the skin while it cleanses.

Thank you, Fashionista, for including us.

The FDA approval of Skinvive for horizontal neck lines marks an important shift in aesthetics: the neck is finally being treated as a true skin-quality area, not an afterthought. Unlike traditional fillers, Skinvive doesn’t add volume — it improves skin quality from within by supporting hydration, smoothness, and texture.

At DR. MACRENE actives, this has always been part of the philosophy. The neck and décolletage need targeted care for hydration, smoothness, firmness, texture, fine lines, and sun damage — whether in-office or at home.

Our High Performance Neck and Décolletage Treatment is the cosmetic formulation developed by dermatologist-scientist Dr. Macrene to support this delicate, often-overlooked area with 50 potent actives and MA37™ technology. Formulated with hyaluronic acids and peptides to help reduce the look of fine lines and wrinkles, green tea and vitamins C & E to help smooth visible roughness, and feverfew and coffee seed extracts to help calm the appearance of redness, it is designed to firm, revive, and improve the look of skin quality over time.

Because skin quality doesn’t stop at the jawline.

Join Dr. Macrene Alexiades at Violet Grey East Hampton

Mini Facials | August 7–8th

Receive a personalized skin analysis and one-on-one consultation to discuss your unique skincare concerns, goals, and treatment recommendations.

Discover the science and learn how to achieve your healthiest, most radiant skin.

Appointments are limited and available by reservation only.

Tap our 'SPA' Highlight to reserve your time.