Medical University Of Vienna
Medical University in Vienna, Austria.
It is currently the largest medical research institute in Austria and the largest medical university in German-speaking countries.
03/12/2024
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01/08/2024
Optimal gestational weight gain associated with improved perinatal outcomes in women with gestational diabetes mellitus: a population-based study in the United States
Background: Optimal gestational weight change (GWC) is little known among pregnant women with gestational diabetes mellitus (GDM).
This study aimed to explore the optimal GWC ranges for women with GDM and validate these ranges compared to the Institute of Medicine (IOM) guidelines.
A population-based cohort study using natality data from the National Center for Health Statistics (NCHS) in the United States included 1,338,460 mother-infant pairs with GDM from 2014 to 2020. Poisson regression models were performed to identify GWC ranges (GDM targets) associated with acceptable risks (< 10% increase) for a severity-weighted composite outcome including preterm birth (PTB) < 37 weeks, large for gestational age (LGA, birthweight > 90th percentile) and small for gestational age (SGA, birthweight < 10th percentile). These targets were validated in individual outcomes including PTB, LGA, SGA, hypertensive disorders of pregnancy, neonatal intensive care unit admission and neonatal respiratory morbidity and compared with the IOM guidelines using logistic regression models with population-attributable fractions (PAFs) calculated.
The severity-weighted composite outcome had a U-shaped or a J-shaped relationship with GWC across body mass index (BMI) categories. The GDM targets were 14.1-20.3 kg, 9.0-17.0 kg, 4.8-13.8 kg, -0.8-10.8 kg, -2.4-8.2 kg, and -8.3-6.0 kg for underweight, normal weight, overweight, class 1 obesity, class 2 obesity, and class 3 obesity, respectively. GWC outside the GDM or the IOM targets was associated with increased adverse perinatal outcomes in validation analyses. PAFs indicated that the IOM guidelines reduced a similar or higher proportion of adverse perinatal outcomes compared to the GDM targets for women with GDM, with the exception of those with class 2 and 3 obesity.
Striatonigral dopaminergic system and its role in adaptive conditioned reflex behavior
Abstract
Neurochemical and pharmacological methods allowed us to study the role of the nigro-striatal dopaminergic system in adaptive conditioned behavior in rats and dogs. The avoidance method showed that the dopamine content in the rat neostriatum increased during the performance of a more difficult task, and the administration of 3 µg of dopamine to the rostral neostriatum accelerated and improved conditioning. Non-adaptive behaviors are accompanied by decreased dopamine levels in the neostriatum. Stimulation of the dopaminergic system of the caudate nucleus in dogs by administration of dopamine (60 µg) and phenamine leads to impairment of the conditioned and unconditioned components of eating behavior. The effects of dopaminomimetics were suppressed by administration of haloperidol (10 µg) and naloxone (0.8 µg) in the same region of the caudate nucleus, indicating the functional interrelation of dopamine- and enkephalin-containing systems of the neostriatum in the regulation of eating behavior. The data obtained and literature references provided a basis for discussion of the role of the nigro-striatal dopaminergic system in the positive modulation of adaptive conditioned behavior in vivo.
Medical University Of Vienna Medical University in Vienna, Austria. It is currently the largest medical research institute in Austria and the largest medical university in German-speaking countries.
18/07/2024
Impact of dietary habits on academic performance of university students
METHOD: Students were asked to participate in an anonymous online survey that asked questions related to health behaviors; participants were asked to report their current GPA. Statistical analysis was performed using JMP software; Standard least squares regression was used to test whether current GPA was associated with different types and rates of weekly food and beverage consumption.
Results: Self-rated GPA did not change with weekly consumption rates of milk, vegetables, green salad, fruit juice, or fresh fruit. Breakfast consumption had a positive effect on self-rated GPA, whereas fast food consumption had a negative effect.
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