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A story rooted in tradition.
A system of medicine shaped by time.

Unani Ki Kahaani returns to your screens.
Only on Discovery Channel
Sunday, February 22, at 1 PM

Tune in to witness the story of holistic healing, once again.

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Aak/Madaar/ Ushar ۔۔ آ ک ، مدار ، عشر
(The information in this article is shared only for educational purposes for Registered and qualified Unani Physicians, Researchers, Academicians and students of Unani Medicine, as this is a toxic drug so self medication is strictly prohibited.)

Botanical Name- Calotropis procera
Other species: Calotropis gigantea
🔹 Family
Apocynaceae

🔹 Vernacular Names
Arabic: Ushar
Persian: Kharg
Hindi: Aak / Madar
English: Giant Milkweed, S***m Apple, Crown Flower

🔹 Parts Used
Root
Root bark
Leaves
Milky latex
Flowers

🔹 Temperament (Mizaj)
Hot and Dry in the 3rd degree

🔹 Pharmacological Actions (Af’aal)
Muhallil-e-Awram (Anti-inflammatory)
Musakkin-e-Dard (Analgesic)
Jali (Detergent/Cleansing agent)
Muqarrih (Vesicant)
Mushil-e-Balgham (Phlegmagogue purgative)
Qatil-e-Kirm-e-Shikam (Anthelmintic)
Mu’arriq (Diaphoretic)
Muqawwi-e-Bah (Aphrodisiac in certain formulations)۔

🔹 Therapeutic Uses
Skin diseases – Ringworm, eczema, vitiligo, external piles (topical use)
Arthritis / Sciatica – Leaf poultice
Ascites – Root used as purgative
Intestinal worms
Phlegmatic disorders
Toothache – Latex applied locally (with caution)
Hemorrhoids – External application of latex

🔹 Dosage
Root powder: 250 mg – 1 g
Latex: External use only

⚠️ Internal use should strictly be under supervision of a qualified Unani physician.

🔹 Adverse Effects
Severe vomiting and diarrhea
Gastric irritation
Cardiotoxic effects in higher doses
Skin blistering

🔹 Correctives (Musleh)
Ghee
Milk
Sugar
Roghan-e-Badam (Almond oil)

🔹 Substitute (Badal)
Af’ee
Turbud (in certain conditions)

🔹 Chemical Constituents
Calotropin
Uscharin
Calotoxin
Flavonoids
Triterpenoids
(Some constituents include cardiac glycosides responsible for its toxicity.)

Key Scientific Findings --

1. Pharmacological Evidence (Preclinical Studies)-
Scientific research supports several biological activities of Calotropis procera extracts in lab and animal models:
• Anti-inflammatory & Analgesic activity — extracts from leaves, latex, and roots showed reduction of inflammation and pain responses in experimental models, likely due to flavonoids and triterpenoids.
• Antimicrobial & Antifungal effects — leaf and latex extracts inhibit growth of certain bacteria and fungi in vitro.
• Wound-healing potential — computational (in-silico) and some in-vitro work suggest active compounds (e.g., stigmasterol) might promote wound healing pathways and demonstrate good binding in molecular studies.
• Antioxidant & Neuroprotective actions — extracts have shown ability to counter oxidative stress and reduce certain kinds of tissue damage in experimental systems.
• Antidiabetic enzyme inhibition — leaf extracts inhibited carbohydrate-digesting enzymes (α-glucosidase/α-amylase) in vitro, suggesting potential glucose-modulating effects.
• Hepatoprotective activity — some animal studies showed protective effects against chemically induced liver damage.
ScienceDirect +1
Cureus
Nature
Nature +1
PMC
Biomedical Research and Therapy

2. Traditional & Pharmacological Correlation
Many preclinical reports confirm several of the traditional uses of Calotropis procera (e.g., anti-inflammatory, antimicrobial, analgesic). However, variability in extraction, dose, and formulation means results cannot yet be extrapolated to standardized clinical application.

3. Lack of Clinical Trials in Humans
Despite promising findings in laboratory and animal models, there are no published clinical trials involving human subjects to validate efficacy or establish safe dosage in standard medical practice. More research is needed before C. procera can be recommended with clinical confidence.
PubMed

4. Toxicity Considerations
Preclinical evidence also highlights the possibility of toxicity, especially with latex and high doses, underscoring the need for careful safety evaluation in human studies.

🔹 Summary of Modern Research
Preclinical studies suggest:
Anti-inflammatory activity
Antimicrobial and antifungal properties
Potential anticancer effects
However, further clinical validation is required.

🔹 Precautions
Contraindicated in pregnancy
Use cautiously in cardiac patients
Avoid self-medication
Should be prescribed only by a qualified Unani/Ayurveda physician.

Unani System of Medicine offers a comprehensive approach to health. By focusing on balance, prevention, and personalised care, it considers the unique interplay between an individual and their environment.

PMO India Narendra Modi Prataprao Jadhav AYUSH - UNANI National Medicinal Plants Board All India Institute of Ayurveda, New Delhi Press Information Bureau - PIB, Government of India MyGovIndia

A-GILE
ए-जाइल
प्राकृतिक स्रोतों से प्राप्त पोषण संबंधी सहायता प्रदान करता है। यह भूख और पाचन में सुधार, स्वास्थ्य को पुनर्स्थापित, एक मजबूत शरीर निर्माण, आहार पोषण को अधिकतम करने, शरीर की प्रतिरोधक क्षमता बढ़ाने और दुर्बल करने वाली बीमारियों से शीघ्र स्वास्थ्य लाभ और रिकवरी में मदद करता है।
दिशा: 20 मिली। A-Gile नाश्ते और शाम के भोजन से पहले। बच्चों को आधी खुराक दी जानी चाहिए।
قدرتی ذرائع سے حاصل کردہ غذائی امداد فراہم کرتا ہے۔ یہ بھوک اور ہاضمہ کو بہتر بنانے، صحت کو بحال کرنے، مضبوط جسم بنانے، غذائی غذائیت کو زیادہ سے زیادہ کرنے، جسم کی قوت مدافعت بڑھانے اور کمزور کرنے والی بیماریوں سے صحت یابی کو تیز کرنے میں مدد کرتا ہے۔
ترکیب استعمال: روزانہ بڑوں کے لئے 20 ملی لیٹر ناشتے سے پہلے اور شام کے کھانے سے پہلے اور بچوں کے لئے 10 ملی لیٹر ناشتے سے پہلے اور شام کے کھانے سے پہلے۔
Provides nutritional support drawn from natural sources. It helps improve appetite and digestion, restores health, helps build a strong body, maximises dietary nutrition, raises body resistance and hastens convalescence and recovery from debilitating illness.
Directions: 20 ml. of A-Gile before breakfast and evening meal. Children should be given half the dose.
दवाओं के बारे में अधिक जानकारी प्राप्त करने के लिए या आप किसी भी बीमारी के लिए परामर्श करना चाहते हैं, तो कृप्या रोगी / रोग की पूरी जानकारी - अर्थात, उम्र, मुख्य शिकायतें, सामान्य शिकायतें, बीमारी की अवधि, आदि लिखें। आपके द्वारा दी गई पूरी जानकारी हमें एक उप्युक्त सलाह देने में मदद करेगी। आप हमारे फ़ोन नंबर +91-9555094254 पर सुबह 10 बजे से शाम 5.30 बजे तक फ़ोन भी कर सकते हैं (रविवार और छुट्टी को छोड़कर) या इसी नम्बर पर व्हाट्स एप्प WhatsApp करें, या [email protected] पर ईमेल करें।
دوائوں کے بارے میں مزید معلومات حاصل کرنے کیلئے یا آپ کسی بھی مرض کے متعلق مشورہ کرنا چاہتے ہیں، تو براہ کرم مرض یا مریض کی پوری جانکاری یعنی عمر، خاص شکایات، عمومی شکایات، بیماری کی مدّت، وغیرہ تفصیل سے لکھیں۔ تمام حالات پر غور و فکر کے بعد مناسب نسخہ تجویز کر کے آپکو روانہ کر دیا جائیگا۔ آپ صبح 10 بجے سے شام 5 بجے تک ہمارے فون نمبر 9555094254 پر کال بھی کر سکتے ہیں (اتوار اور چھٹّی کے علاوہ)۔ یا اسی نمبر پر واٹس ایپ کریں، یا [email protected] پر ای میل کریں۔

Sciatic Pain (ʿIrq-un-Nasāʼ)
✔ Root-cause treatment
✔ Natural pain relief
✔ Strengthens nerves
Unani medicine—where tradition meets clinical wisdom.

Finance Minister Nirmala Sitharaman emphasised a renewed commitment to strengthening by expanding national institutes, modernising , and raising global standards for traditional medicine through upgraded facilities.