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Atropine

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Atropine is a tropane alkaloid and anticholinergic medication used to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate, and to decrease saliva production during surgery.[6] It is typically given intravenously or by injection into a muscle.[6] Eye drops are also available which are used to treat uveitis and early amblyopia.[7][8] The intravenous solution usually begins working within a minute and lasts half an hour to an hour.[5] Large doses may be required to treat some poisonings.[6]

AtropineClinical dataTrade namesAtropen, othersOther namesDaturin [1]AHFS/Drugs.comMonographMedlinePlusa682487License data

US DailyMed: Atropine

Pregnancy
category

AU: A

Routes of
administrationBy mouth, intravenous, intramuscular, re**al, ophthalmicDrug classantimuscarinic (anticholinergic)ATC code

A03BA01 (WHO) S01FA01 (WHO)

Legal statusLegal status

AU: S4 (Prescription only) [2]

US: ℞-only [3][4]

Pharmacokinetic dataBioavailability25%Metabolism≥50% hydrolysed to tropine and tropic acidOnset of actionc. 1 minute[5]Elimination half-life2 hoursDuration of action30 to 60 min[5]Excretion15–50% excreted unchanged in urineIdentifiers

IUPAC name

(RS)-(8-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenylpropanoate

CAS Number

51-55-8 

PubChem CID

174174

IUPHAR/BPS

320

DrugBank

DB00572 

ChemSpider

10194105 

UNII

7C0697DR9I

KEGG

D00113 

ChEBI

CHEBI:16684 

ChEMBL

ChEMBL9751 

CompTox Dashboard (EPA)

DTXSID4020113 

ECHA InfoCard100.000.096 Chemical and physical dataFormulaC17H23NO3Molar mass289.375 g·mol−13D model (JSmol)

Interactive image

SMILES

CN3[C@H]1CC[C@]3C[C@](C1)OC(=O)C(CO)c2ccccc2

InChI

InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16? 

Key:RKUNBYITZUJHSG-SPUOUPEWSA-N 

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Common side effects include a

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