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How It Works
Tirzepatide is unique because it is a dual agonist that mimics two natural gut hormones: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). This dual action helps with weight loss by:
Reducing appetite and cravings by signaling to the brain that you are full.
Slowing down digestion, which makes you feel fuller for longer after eating.
Improving metabolic health, including better blood sugar and cholesterol levels.
Expected Results
Clinical trials have shown significant, dose-dependent weight loss when used alongside a reduced-calorie diet and increased physical activity.
Dose (once weekly) Average % Weight Loss (over 72 weeks) Average Absolute Weight Loss (over 72 weeks)
5 mg ~15% ~34 lbs
10 mg ~19.5% ~48 lbs
15 mg ~20.9% ~48 lbs
A significant majority of participants (85-91%) achieved a weight reduction of 5% or more.
Who Can Take It
Tirzepatide for weight management (Zepbound) is FDA-approved for adults with:
Obesity (Body Mass Index (BMI) of 30 or higher), or
Overweight (BMI of 27 or higher) with at least one weight-related medical condition (e.g., high blood pressure, high cholesterol, type 2 diabetes, or obstructive sleep apnea).
It is not for use in patients with type 1 diabetes or a history of severe allergic reactions to the medication. A healthcare provider will determine if you are an eligible candidate.
Common Side Effects and Considerations
Most side effects are gastrointestinal in nature, mild to moderate in severity, and typically occur during the initial dose-escalation period.
Common side effects: Nausea, diarrhea, vomiting, constipation, and decreased appetite.
Important considerations: Continued use of the medication is necessary to maintain weight loss; weight regain is likely after stopping treatment.
Consult with a licensed medical professional to discuss if tirzepatide is the right option for your health needs.
Can Tirzepatide (Mounjaro, Zepbound) Help You Lose Weight?
Can Tirzepatide (Mounjaro, Zepbound) Help You Lose Weight? * Tirzepatide (Mounjaro) is FDA approved for Type 2 diabetes. People using it tend to lose weight. In...

GoodRx

Tirzepatide Once Weekly for the Treatment of Obesity
Abstract * Background. Obesity is a chronic disease that results in substantial global morbidity and mortality. The efficacy and safety of tirzepatide, a novel ...

The New England Journal of Medicine
Tirzepatide's Mechanism of Action: 7 Ways It Works for Weight ... - GoodRx
Key takeaways: * Tirzepatide is a once-weekly injectable medication that's available under two brand names: Mounjaro (for Type 2 diabetes) and Zepbound (for wei...

GoodRx

FDA Approves New Medication for Chronic Weight Management
Zepbound should not be used in patients with a history of severe allergic reaction to tirzepatide (its active ingredient) or to any of its other ingredients. Pa...

Food and Drug Administration (.gov)
Tirzepatide - StatPearls - NCBI Bookshelf
Tirzepatide is not approved for the treatment of type 1 diabetes mellitus (T1DM) and has not undergone studies in patients with pancreatitis. Tirzepatide can al...

National Institutes of Health (NIH) | (.gov)
Weight Loss Medication for Adults with Obesity or Overweight - Zepbound
Zepbound® (tirzepatide) is an injectable weight loss medication that may help adults with obesity, or some adults with overweight who also have weight-related m...

Zepbound® (tirzepatide) Injection

The promise of tirzepatide: A narrative review of metabolic benefits
Highlights * • Tirzepatide administration resulted in significant weight loss. * Tirzepatide significantly reduced food intake and overall appetite. * Tirzepati...

ScienceDirect.com

Why Tirzepatide is Your Best Weight Loss Ally | Texas Medical Institute
Why Tirzepatide is Your Best Weight Loss Ally. ... Losing weight can be a challenging and emotional experience. For many, traditional approaches such as diet an...

Texas Medical Institute

18 Possible Side Effects of Tirzepatide (Mounjaro, Zepbound) - GoodRx
Key takeaways: * Tirzepatide is a once-weekly injectable medication that can be prescribed for Type 2 diabetes (Mounjaro) or chronic weight management (Zepbound...

GoodRx

Tirzepatide as Compared with Semaglutide for the Treatment of ...
Abstract * Background. Tirzepatide and semaglutide are highly effective medications for obesity management. The efficacy and safety of tirzepatide as compared w...

The New England Journal of Medicine
Continued Treatment With Tirzepatide Is Necessary to Maintain ...
Data Analysis: Intention-to-treat analysis using 2-sample t test for primary outcome. Funding: Eli Lilly, manufacturer of tirzepatide, designed and oversaw the ...

American College of Gastroenterology

Tirzepatide (subcutaneous route) - Side effects & dosage - Mayo Clinic
Description. Tirzepatide injection is used to treat type 2 diabetes. It is used together with diet and exercise to help control your blood sugar. Tirzepatide is...

Mayo Clinic

FDA Approves Tirzepatide for Treating Obesity
FDA ( Food and Drug Administration (FDA ) Approves Tirzepatide for Treating Obesity The US Food and Drug Administration (FDA) has approved tirzepatide for chron...

Medscape
Tirzepatide: A Novel Weight Loss Medication
This highlights the importance of long-term adherence to tirzepatide treatment for maintaining weight loss and underscores the chronic nature of obesity as a co...

Rivas Medical Weight Loss

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