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Protandim® NRF1 Synergizer™*

Support your cells’ mitochondrial health and function to promote power, energy, and healthy aging.*

NRF1
C33H44F2N2O3

Omaveloxolone
1474034-05-3
RTA-408
RTA 408
Nrf1-activator-1

Omaveloxolone is a member of the synthetic oleanane triterpenoid class of compounds and an activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2, Nfe2l2), with potential chemopreventive activity. Upon administration, omaveloxolone activates the cytoprotective transcription factor Nrf2. In turn, Nrf2 translocates to the nucleus, dimerizes with a small Maf protein (sMaf), and binds to the antioxidant response element (ARE). This induces the expression of a number of cytoprotective genes, including NAD(P)H quinone oxidoreductase 1 (NQO1), sulfiredoxin 1 (Srxn1), heme oxygenase-1 (HO1, HMOX1), superoxide dismutase 1 (SOD1), gamma-glutamylcysteine synthetase (gamma-GCS), thioredoxin reductase-1 (TXNRD1), glutathione S-transferase (GST), glutamate-cysteine ligase catalytic subunit (Gclc) and glutamate-cysteine ligase regulatory subunit (Gclm), and increases the synthesis of the antioxidant glutathione (GSH). Nrf2, a leucine zipper transcription factor, plays a key role in the maintenance of redox balance and cytoprotection against oxidative stress.

Omaveloxolone has been used in trials studying the treatment of Relapsed, Refractory Melanoma and Metastatic or Incurable Non-small Cell Lung Cancer.

---- Power Up to Perform ----
The pathway to power. Your mitochondria power every cell in your body, from the ones that make up your heart and brain to the ones in your bones and muscles. Your body’s energy and performance start with mitochondria. But mitochondria decline with age or when stressed. Protandim NRF1 Synergizer activates the NRF1 pathway, which is responsible for mitochondrial health. Think of mitochondria as power generators, and NRF1 Synergizer creates more of them and provides the nutrients they need immediately. This science-backed supplement enhances cellular health and energy to improve your overall performance.*

Benefits
Improves performance through energy function *
Supports cellular health*
Increases cellular energy, or adenosine triphosphate (ATP) *

What's Inside?

Acetyl L-Carnitine
An amino acid naturally produced in the body and, combined with alpha lipoic acid, boosts mitochondria production, supports healthy cellular aging, and protects against normal oxidation of RNA and mitochondria.*

Quercetin
A polyphenol that helps to protect the mitochondria and their function—which supports ATP synthesis.*

Alpha-Lipoic Acid
Called ALA, it’s made in the body and helps turn glucose into energy that the cell can use and can protect all parts of the cell (including the mitochondria) from free radicals.*

Grape Extract
Contains powerful natural stilbenoids (resveratrol and viniferin) known to support healthy aging by activating the NRF1 protein and other age-related cell-signaling pathways.*

Coenzyme Q10
Made in the body and plays a key role in ATP production and, combined with alpha lipoic acid, supports cellular energy levels, healthy stress response, and antioxidant defense mechanisms.*

https://genphilbroz2429.lifevantage.com/ph-en/shop/protandim-nrf1

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