Dr. Jocelyn Ong-Sy

Dr. Jocelyn Ong-Sy

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A board certified member of the Philippine Obstetrics and Gynecologic Society

Specializes in Pregnancy & Childbirth, Birth control & Contraception, Pelvic and Breast mass, STD related problems , PAP smear concerns etc.

🤓𝗦𝗸𝗶𝗻 𝗰𝗵𝗮𝗻𝗴𝗲𝘀 𝗮𝗿𝗲 𝗼𝗻𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗺𝗼𝘀𝘁 𝗼𝘃𝗲𝗿𝗹𝗼𝗼𝗸𝗲𝗱 𝘀𝘆𝗺𝗽𝘁𝗼𝗺𝘀 𝗼𝗳 𝗽𝗲𝗿𝗶𝗺𝗲𝗻𝗼𝗽𝗮𝘂𝘀𝗲.

👉🏻Many women suddenly experience itching, skin sensitivity, or unexplained irritation, often without a rash.

This isn’t just about dryness.

👉🏻Estrogen plays a key role in maintaining the structure and resilience of the skin. It supports collagen production, hydration, and barrier integrity. As estrogen fluctuates during perimenopause, the skin can become thinner, drier, and more reactive.

But there’s another layer.

💡Estrogen also interacts with mast cells, which regulate histamine release in the body. When estrogen levels fluctuate, mast cells can become more reactive, leading to increased histamine signaling.

𝗧𝗵𝗶𝘀 𝗰𝗮𝗻 𝘀𝗵𝗼𝘄 𝘂𝗽 𝗮𝘀:
• itching
• flushing
• headaches
• sleep disruption
• anxiety

For many women, these symptoms seem unrelated but they’re connected through hormone-driven inflammatory pathways.

𝗨𝗻𝗱𝗲𝗿𝘀𝘁𝗮𝗻𝗱𝗶𝗻𝗴 𝘁𝗵𝗲 𝗽𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝘆 𝗯𝗲𝗵𝗶𝗻𝗱 𝘁𝗵𝗲𝘀𝗲 𝘀𝘆𝗺𝗽𝘁𝗼𝗺𝘀 𝗵𝗲𝗹𝗽𝘀 𝗿𝗲𝗺𝗼𝘃𝗲 𝘁𝗵𝗲 𝗰𝗼𝗻𝗳𝘂𝘀𝗶𝗼𝗻 𝗮𝗻𝗱 𝘁𝗵𝗲 𝘀𝗲𝗹𝗳-𝗱𝗼𝘂𝗯𝘁 𝗺𝗮𝗻𝘆 𝘄𝗼𝗺𝗲𝗻 𝗲𝘅𝗽𝗲𝗿𝗶𝗲𝗻𝗰𝗲 𝗱𝘂𝗿𝗶𝗻𝗴 𝘁𝗵𝗶𝘀 𝘁𝗿𝗮𝗻𝘀𝗶𝘁𝗶𝗼𝗻.

👉🏻Follow for continued clinical education on women’s hormones.

📌Save this post for later or share it with someone navigating perimenopause.

𝘏𝘢𝘷𝘦 𝘺𝘰𝘶 𝘯𝘰𝘵𝘪𝘤𝘦𝘥 𝘤𝘩𝘢𝘯𝘨𝘦𝘴 𝘪𝘯 𝘺𝘰𝘶𝘳 𝘴𝘬𝘪𝘯 𝘥𝘶𝘳𝘪𝘯𝘨 𝘵𝘩𝘪𝘴 𝘴𝘵𝘢𝘨𝘦? What helped?
.
.
#histamine #perimenopauseallergies #mastcellactivation #lexiyoonp

24/05/2026

🤓𝗦𝗸𝗶𝗻 𝗰𝗵𝗮𝗻𝗴𝗲𝘀 𝗮𝗿𝗲 𝗼𝗻𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗺𝗼𝘀𝘁 𝗼𝘃𝗲𝗿𝗹𝗼𝗼𝗸𝗲𝗱 𝘀𝘆𝗺𝗽𝘁𝗼𝗺𝘀 𝗼𝗳 𝗽𝗲𝗿𝗶𝗺𝗲𝗻𝗼𝗽𝗮𝘂𝘀𝗲. 👉🏻Many women suddenly experience itching, skin sensitivity, or unexplained irritation, often without a rash. This isn’t just about dryness. 👉🏻Estrogen plays a key role in maintaining the structure and resilience of the skin. It supports collagen production, hydration, and barrier integrity. As estrogen fluctuates during perimenopause, the skin can become thinner, drier, and more reactive. But there’s another layer. 💡Estrogen also interacts with mast cells, which regulate histamine release in the body. When estrogen levels fluctuate, mast cells can become more reactive, leading to increased histamine signaling. 𝗧𝗵𝗶𝘀 𝗰𝗮𝗻 𝘀𝗵𝗼𝘄 𝘂𝗽 𝗮𝘀: • itching • flushing • headaches • sleep disruption • anxiety For many women, these symptoms seem unrelated but they’re connected through hormone-driven inflammatory pathways. 𝗨𝗻𝗱𝗲𝗿𝘀𝘁𝗮𝗻𝗱𝗶𝗻𝗴 𝘁𝗵𝗲 𝗽𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝘆 𝗯𝗲𝗵𝗶𝗻𝗱 𝘁𝗵𝗲𝘀𝗲 𝘀𝘆𝗺𝗽𝘁𝗼𝗺𝘀 𝗵𝗲𝗹𝗽𝘀 𝗿𝗲𝗺𝗼𝘃𝗲 𝘁𝗵𝗲 𝗰𝗼𝗻𝗳𝘂𝘀𝗶𝗼𝗻 𝗮𝗻𝗱 𝘁𝗵𝗲 𝘀𝗲𝗹𝗳-𝗱𝗼𝘂𝗯𝘁 𝗺𝗮𝗻𝘆 𝘄𝗼𝗺𝗲𝗻 𝗲𝘅𝗽𝗲𝗿𝗶𝗲𝗻𝗰𝗲 𝗱𝘂𝗿𝗶𝗻𝗴 𝘁𝗵𝗶𝘀 𝘁𝗿𝗮𝗻𝘀𝗶𝘁𝗶𝗼𝗻. 👉🏻Follow for continued clinical education on women’s hormones. 📌Save this post for later or share it with someone navigating perimenopause. 𝘏𝘢𝘷𝘦 𝘺𝘰𝘶 𝘯𝘰𝘵𝘪𝘤𝘦𝘥 𝘤𝘩𝘢𝘯𝘨𝘦𝘴 𝘪𝘯 𝘺𝘰𝘶𝘳 𝘴𝘬𝘪𝘯 𝘥𝘶𝘳𝘪𝘯𝘨 𝘵𝘩𝘪𝘴 𝘴𝘵𝘢𝘨𝘦? What helped? . . #histamine #perimenopauseallergies #mastcellactivation #lexiyoonp

24/05/2026

23/05/2026

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