Health and Wellness solution

A BLESSED EASTER SUNDAY
JESUS IS RAISED, ALLELUIA!
April 12, 2020

“THIS IS THE DAY THE LORD HAS MADE;
WE WILL REJOICE AND BE GLAD IN IT.”
— Psalms 118: 24 —

MATTHEW 28: 5-7: ‘The angel said to the women, "Do not be afraid; for I know that you are looking for Jesus who has been crucified. He is not here, for HE HAS RISEN, just as He said. Come, see the place where He was lying. Go quickly and tell His disciples that He has risen from the dead; and behold, He is going ahead of you into Galilee, there you will see Him; behold, I have told you.”’

ETERNAL FATHER, the resurrection of JESUS CHRIST, Your Son has given us new life and renewed hope. Help us to live as new people in pursuit of the Christian ideal. Grant us wisdom to know what we must do, the will to want to do it, the courage to undertake it, the perseverance to continue to do it, and the strength to complete it. Oh God, as we renew our Baptismal vows, help us to be made worthy of Eternal Life, that we may always seek to do Your will in our hearts and minds, that we may show others Your saving grace and Your love. We ask this through Christ, our Lord, Who lives and reign with You and the Holy Spirit, One God, forever and ever. Amen.

The Cyber Security Philippines - CERT warned that apart from the possibility that the filter could be reversed, users who post compromising videos on TikTok could be targeted by pedophiles and s*x offenders as the challenge showcases teens who are “gullible and exploitable.”
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Narito po ang aming bagong delivery lead-time effective immediately until further notice po. Salamat po.

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Why does soap work so well on the SARS-CoV-2, the coronavirus and indeed most viruses? Because it is a self-assembled nanoparticle in which the weakest link is the lipid (fatty) bilayer.

The soap dissolves the fat membrane and the virus falls apart like a house of cards and "dies", or rather, we should say it becomes inactive as viruses aren’t really alive. Viruses can be active outside the body for hours, even days.

Disinfectants, or liquids, wipes, gels and creams containing alcohol (and soap) have a similar effects but are not really quite as good as normal soap. Apart from the alcohol and soap, the “antibacterial agents” in these products don't affect the virus structure much at all. Consequently, many antibacterial products are basically just an expensive version of soap in terms of how they act on viruses. Soap is the best but alcohol wipes are good when soap is not practical or handy (e.g. office receptions).

But why exactly is soap so good? To explain that, I will take you through a bit of a journey through supramolecular chemistry, nanoscience and virology. I try to explain this in generic terms as much as possible, which means leaving some specialist chemistry terms out. This is a rather long post, but hopefully you enjoy it.

I point out to that while I am expert in supramolecular chemistry and the assembly of nanoparticles, I am not a virologists. The first image here is from an excellent post here which is dense with good virology info: https://t.co/73TurPhxOE?amp=1

I have always been fascinated by viruses as I see them as one of them most spectacular examples of how supramolecular chemistry and nanoscience can converge.

Most viruses consist of three key building blocks: RNA, proteins and lipids.The RNA is the viral genetic material -it is very similar to DNA. The proteins have several roles including breaking into the target cell, assist with virus replication and basically to be a key building block (like a brick in a house) in the whole virus structure.

The lipids then form a coat around the virus, both for protection and to assist with its spread and cellular invasion. The RNA, proteins and lipids self-assemble to form the virus. Critically, there are no strong “covalent” bonds holding these units together.

Instead the viral self-assembly is based on weak “non-covalent” interactions between the proteins, RNA and lipids. Together these act together like a Velcro so it is very hard to break up the self-assembled viral particle. Still, we can do it (e.g. with soap!).

Most viruses, including the coronavirus, are between 50-200 nanometers – so they are truly nanoparticles. Nanoparticles have complex interactions with surfaces they are on. Same with viruses. Skin, steel, timber, fabric, paint and porcelain are very different surfaces.

When a virus invades a cell, the RNA “hijacks” the cellular machinery like a computer virus (!) and forces the cell to start to makes a lot of fresh copies of its own RNA and the various proteins that make up the virus.

These new RNA and protein molecules, self-assemble with lipids (usually readily present in the cell) to form new copies of the virus. That is, the virus does not photocopy itself, it makes copies of the building blocks which then self-assemble into new viruses!

All those new viruses eventually overwhelm the cell and it dies/explodes releasing viruses which then go on to infect more cells. In the lungs, some of these viruses end up in the airways and the mucous membranes surrounding these.

When you cough, or especially when you sneeze, tiny droplets from the airways can fly up to 10 meters (30 ft)! The larger ones are thought to be main coronavirus carriers and they can go at least 2 m (7 ft). Thus – cover your coughs & sneezes people!

These tiny droplets end on surfaces and often dry out quickly. But the viruses are still active! What happens next is all about supramolecular chemistry and how self-assembled nanoparticles (like the viruses) interact with their environment!

Now it is time to introduce a powerful supramolecular chemistry concept that effectively says: similar molecules appear to interact more strongly with each other than dissimilar ones. Wood, fabric and not to mention skin interact fairly strongly with viruses.

Contrast this with steel, porcelain and at least some plastics, e.g. teflon. The surface structure also matter – the flatter the surface the less the virus will “stick” to the surface. Rougher surfaces can actually pull the virus apart.

So why are surfaces different? The virus is held together by a combination of hydrogen bonds (like those in water) and what we call hydrophilic or “fat-like” interactions. The surface of fibres or wood for instance can form a lot of hydrogen bonds with the virus.

In contrast steel, porcelain or teflon do not form a lot of hydrogen bond with the virus. So the virus is not strongly bound to these surfaces. The virus is quite stable on these surface whereas it doesn’t stay active for as long on say fabric or wood.

For how long does the virus stay active? It depends. The SARS-CoV-2 coronavirus is thought to stay active on favourable surfaces for hours, possibly a day. Moisture (“dissolves”), sun light (UV light) and heat (molecular motions) all make the virus less stable.

The skin is an ideal surface for a virus! It is “organic” and the proteins and fatty acids in the dead cells on the surface interact with the virus through both hydrogen bonds and the “fat-like” hydrophilic interactions.

So when you touch say a steel surface with a virus particle on it, it will stick to your skin and hence get transferred onto your hands. But you are not (yet) infected. If you touch your face though, the virus can get transferred from your hands and on to your face.

And now the virus is dangerously close to the airways and the mucus type membranes in and around your mouth and eyes. So the virus can get in…and voila! You are infected (that is, unless your immune system kills the virus).

If the virus is on your hands you can pass it on by shaking someone’s else hand. Kisses, well, that's pretty obvious…It comes without saying that if someone sneezes right in your face you are kind of stuffed.

So how often do you touch your face? It turns out most people touch the face once every 2-5 minutes! Yeah, so you at high risk once the virus gets on your hands unless you can wash the active virus off.

So let’s try washing it off with plain water. It might just work. But water “only” competes with the strong “glue-like” interactions between the skin and virus via hydrogen bonds. They virus is quite sticky and may not budge. Water isn’t enough.

Soapy water is totally different. Soap contains fat-like substances knowns as amphiphiles, some structurally very similar to the lipids in the virus membrane. The soap molecules “compete” with the lipids in the virus membrane. This is more or less how soap also removes normal dirt of the skin (see picture).

The soap molecules also compete with a lot other non-covalent bonds that help the proteins, RNA and the lipids to stick together. The soap is effectively “dissolving” the glue that holds the virus together. Add to that all the water.

The soap also outcompetes the interactions between the virus and the skin surface. Soon the viruses get detached and fall a part like a house of cards due to the combined action of the soap and water. The virus is gone!

The skin is quite rough and wrinkly which is why you do need a fair amount of rubbing and soaking to ensure the soap reaches very crook and nanny on the skin surface that could be hiding active viruses.

Alcohol based products, which pretty includes all “disinfectants” and “antibacterial” products contain a high-% alcohol solution, typically 60-80% ethanol, sometimes with a bit of isopropanol as well and then water + a bit of a soap.

Ethanol and other alcohols do not only readily form hydrogen bonds with the virus material but as a solvent, are more lipophilic than water. Hence alcohol do also dissolve the lipid membrane and disrupt other supramolecular interactions in the virus.

However, you need a fairly high concentration (maybe +60%) of the alcohol to get a rapid dissolution of the virus. Vodka or whiskey (usually 40% ethanol - see picture), will not dissolve the virus as quickly. Overall alcohol is not quite as good as soap at this task.

Nearly all antibacterial products contain alcohol and some soap and this does help killing viruses. But some also include “active” bacterial killing agents, like triclosan. Those, however, do basically nothing to the virus!

To sum up, viruses are almost like little grease-nanoparticles. They can stay active for many hours on surfaces and then get picked up by touch. They then get to our face and infect us because most of us touch the face quite frequently.

Water is not very effective alone in washing the virus off our hands. Alcohol based product work better. But nothing beats soap – the virus detaches from the skin and falls apart very readily in soapy water.

Here you have it – supramolecular chemistry, the way molecules interact with each other (see picture) and nanoscience tell us not only a lot about how the virus self-assembled into a functional active menace, but also how we can beat viruses with something as simple as soap.
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Please read with proper understanding as they say...

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PAANO NAPUPUKSA NG SABON ANG CORONAVIRUS?
ni Dr. Iris Thiele C. Isip Tan

Ang picture na nakalakip sa post ay galing kay Ferris Jabr sa Twitter.

Kaya coronavirus ang tawag sa virus ay parang may korona ng tinik ito. Sa larawan makikita ang spike proteins na nasa paligid ng balot ng virus. Sumisingit sa pagitan ng mga tinik na ito ang sabon, kaya nasisira ang virus. At ang maganda pa dito, nagbubuo ng micelles ang sabon. Yung mga pira-pirasong virus ay nakukulong sa loob ng micelle. Ang mga micelles na ito ay sumasama na sa tubig pag naghugas ng kamay. At yun ang kinaganda ng sabon at tubig - napapatay na nga ang virus, natatanggal pa sa kamay.

Kaya sinasabi ng mga eksperto na maghugas ng kamay gamit ang sabon at tubig, at kung hindi puwede saka lang ang alcohol o hand sanitizer. Napupuksa din kasi ng alcohol o hand sanitizer ang coronavirus pero puwedeng nasa mga kamay mo pa rin ang mga patay na coronavirus. Kaya kung meron din lang naman na tubig at sabon, maghugas ng kamay para ang coronavirus ay maanod na sa lababo papunta sa drain.

Ingat po tayong lahat. Kaya natin ‘to Pilipinas!

While other people are busy buying grocery items for their families, a netizen witnessed a small act of kindness while shopping at a grocery store in Makati City last March 11, 2020.

Uploader Lane said she overheard a conversation between a woman and an elderly man while waiting in line at a grocery store.

“Kuha pa po kayo ng tinapay, kape, asukal... ako po ang magbabayad,” Lane quoted the woman as saying.

According to Lane, there are only a few canned goods and bottles of alcohol inside the grocery basket of the elderly man.

He was thinking twice if he would accept the woman’s offer to shoulder his bill. He later on decided to add more items to his basket but the woman insisted that he should add more.

“Yan lang po kinuha niyo? Kuha pa po kayo. Dagdagan niyo pa po, ako po ang magbabayad,” the woman said referring to the two small packs of baked goods that the man got from the shelves.

While he was away to get more, the woman approached her companion and they both added other items to his basket.

“So habang wala pa si Manong, napupuno na ang basket niya kalalagay nila girl and kasama niya ng mga necessity items,” Lane said.

“Pagdating ni Manong, nagulat na lang siya sa dami ng laman ng basket niya. Makikitang happy and overwhelmed na rin si Manong,” she added.

Lane said that her faith in humanity was restored upon witnessing the kindness of the woman amid stories of panic-buying and hoarding due to the threat of COVID-19

“We should spread kindness nga pala lalo na sa panahon ngayon,” Lane said.

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