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Product Description
HEART PROTECTION WITH PROCARDIN

NO NEED FOR BYPASS

HOW PATIENT DEVELOPS ANGINA?

Atherosclerotic plaque formed in large & middle size arteries of adults.

When plaque reduces luminal diameter by more than about 70% Angina pectoris develop.

Accumulation of cholesterol rich gruel expansion of fibrous tissue involvement of Monocytes Lymphocytes and mast cell.

Hardening & thickening of blood vessels by the deposition of cholesterol (Hyper Choldestermia0 and lipids (Hyper Lipdimia).

WHY PROCARDIN IS AN IDEAL CHOICE.

Procardin is an ideal combination of following unique & different Herbs.

Composition:

Reishi Mushroom (Ganoderma Lucidum)
Sea Buckthorn (Hippophae rhamnoides)
Lyceum Barbarum (Gigi)
Allium Sativum (Garlic)
Nattokinase (Produce Through Fermentayion)
Apple Phenols
Sorbotol
Sea Buckthorn and Heart Disease:

A recent review of scientific data suggests that sea buckthorn may have beneficial effects on heart disease.

Sea buckthorn (Hippophae rhamnoides) (Procardin)is found throughout Europe and Asia, particularly eastern Europe and central Asia. Traditionally, the plant's orange fruit and the oil from its pulp and seeds have been used to treat dermatological conditions, coughing, congestion and digestive disorders.

The results of the recent review, published in the Journal of Functional Foods, suggest that sea buckthorn(Procardin) may help prevent and treat heart disease. Preliminary evidence, according to the authors, suggests that sea buckthorn may have cholesterol-lowering, antiatherogenic, and anti-blood clotting effects.

However, the authors noted that the reviewed studies had small sample sizes and were of short duration. Larger, well-designed trials are needed to confirm these early findings.

References:

Natural Standard: The Authority on Integrative Medicine.
XU YJ, Kaur M, Dhillon RS, et al. Health benefits of sea buckthorn for the prevention of cardiovascular diseases. Journal of Functional Foods. 2011. doi:10.1016/j.jff.2011.01.001.

LYCIUM BARBARUM (Gogi):

barbarum berry and juice has long been used as antioxidants. L. barbarum berry contains significant amounts of the well-studied antioxidant carotenoid zeaxanthin.
1: It has been found that carotenoid intake also reduces the risk of certain forms of cardiovascular disease, stroke, and cancer.

2: Polysaccharides, isolated from L. barbarum berry, also have been reported to have antioxidant activity.

3: Antioxidant polysaccharides from L. barbarum berry have been reported to help protect against liver damage by reducing oxidative stress in laboratory studies.

4: L. barbarum berry is used traditionally in blood sugar regulation. To support this use, a laboratory animal study found that administration of L. barbarum berry polysaccharide for 3 weeks improved insulin resistance and lipid profile in rats that were non-insulin dependent diabetes mellitus (NIDDM).

5: The authors concluded that the mechanism of blood glucose balance might be involved in increasing cell-surface level of GLUT4, improving GLUT4 trafficking and intracellular insulin signaling.

6: Another 10 day laboratory animal study found that 3 different extracts of L. barbarum berry (a fruit/water decoction, crude polysaccharide extract and purified polysaccharide fraction) significantly reduced blood glucose levels and serum total cholesterol (TC) and triglyceride (TG) concentrations and at same time markedly increase high density lipoprotein cholesterol levels.

7: In vitro studies report that L. barbarum extracts also seem to inhibit the growth of and cause apoptosis in certain cancer cell lines, increase macrophage phagocytosis, increase IL-2 expression reduce lipid peroxidation.

8: The studies showed that pre-treatment using L. barbarum polysaccharides effectively protected neurons against A beta-induced apoptosis by reducing the release of lactate dehydrogenase (LDH) and by reducing the activity of both caspase-3 and -2, but not caspase-8 and -9.

Procardin Honey:

Honey Reduces Heart Disease Risk
Eating honey can lower the risk of heart disease, according to a preliminary study published in the Journal of Medicinal Food (2004;1:100–7). The beneficial effect of honey occurred despite the fact that two of its constituents (sucrose and fructose) are known to have a negative effect on heart disease risk factors.
Made by honeybees, honey’s sweet taste comes from the three sugars that are its primary constituents: sucrose, glucose, and fructose. A diet high in table sugar (sucrose) is known to increase the risk of obesity, insulin resistance, and high blood pressure. Sucrose also reduces the levels of beneficial HDL cholesterol and increases triglyceride levels. Fructose has similar effects to those of sucrose. Honey is a complex food; aside from sugars, it contains a number of potentially beneficial enzymes, amino acids, pigments, pollen, wax, and traces of nutrients from both bees and plants. It is known to have wound-healing and antibacterial properties, and some studies have suggested that eating honey can reduce blood levels of some markers that are linked to an increased risk of heart disease.
A number of chemicals in the blood can be monitored to measure heart disease risk. For many years, blood levels of cholesterol and LDL (“bad”) cholesterol have been used, and more recently homocysteine and C-reactive protein (CRP) have been added to the list of heart disease risk factors. People with high homocysteine levels have higher rates of heart disease, cancer, and some other conditions; homocysteine levels can be lowered by supplementing with vitamins B6, B12, and folic acid. High CRP levels have also been shown to predict heart disease. Levels of CRP are increased by smoking, high blood pressure, obesity, and chronic gum disease, and when there is inflammation in the body; antioxidants, vitamin E, and some medications, such as statin drugs, can lower CRP levels.
The current study involved seven small trials with between five and nine participants. In each trial, blood was examined before and after drinking solutions containing honey, glucose, and artificial honey (approximately half glucose and half fructose). The solutions used in each trial contained between 1 and 3 ounces of honey, glucose, or glucose and fructose. Healthy people experienced an immediate slight decrease in total cholesterol, LDL cholesterol, and triglyceride levels after drinking the honey solution but not after glucose and artificial honey solutions. This trend persisted in healthy people drinking the honey solution for 15 days, after which HDL cholesterol levels rose and homocysteine levels dropped. The effect of taking the honey solution every day for fifteen days was even more pronounced in people with high cholesterol: total cholesterol levels dropped by 8%, LDL cholesterol levels dropped by 11%, and CRP levels dropped by 57%.
The results of this study suggest that honey may have a unique positive effect on risk factors for heart disease. In a relatively short time, people with high cholesterol taking honey experienced modest reductions in cholesterol levels, and, perhaps more importantly, dramatic reductions in CRP. It appears that CRP might be as important a risk factor for heart disease as cholesterol, and that the benefits of using statin medications might have more to do with their ability to lower CRP levels than their effect on cholesterol levels. Thus, while there is a good deal of evidence that eating refined sugars such as sucrose and fructose may increase the risk of heart disease, this study suggests that eating honey is not only safe, but may actually be good for the heart. Despite its possible benefits, one should be careful not to overdo it as eating too much honey would add extra calories, potentially leading to obesity.

Interaction and Depletions:

Interaction with other Herbs

No documentation

Interaction with Drugs

Based on pharmacology, use with caution in individuals taking blood-thinning medications, such as aspirin or warfarin (Coumadin).

Precautions and Contraindications:

Side effects

barbarum fruit has been reported safe in recommended doses. L. barbarum berry has been thought to increase anticoagulant therapy in case reports, so use with caution if a bleeding disorder exists. Discontinue if allergy occurs.
Pregnancy

No documentation
Age limitation

No documentation
Adverse reaction

No documentation
References:

Krinsky, N et al. Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annu Rev Nutr 23.2003:171-201.
Kritchevsky SB. Beta-carotene, carotenoids and the prevention of coronary heart disease. J Nutr. 1999; 129:5-8.
Lin CL, Wang CC, Chang SC, Inbaraj BS, Chen BH. Ant oxidative activity of polysaccharide fractions isolated from Lycium barbarum Linnaeus. Int J Biol Macromol. 1Aug2009;45(2):146-151.
Li XM, Ma YL, Liu XJ. Effect of the Lycium barbarum polysaccharides on age-related oxidative stress in aged mice. J Ethnopharmacol. 22May2007;111(3):504-511.
Yu MS, Ho YS, So KF, Yuen WH, Chang RC. Cytoprotective effects of Lycium barbarum against reducing stress on endoplasmic reticulum.Int J Mol Med. Jun2006;17(6):1157-1161.
Zhao R, Li Q, Xiao B. Effect of Lycium barbarum polysaccharide on the improvement of insulin resistance in NIDDM rats. Yakugaku Zasshi. Dec2005;125(12):981-988.
Luo Q, Cai Y, Yan J, Sun M, Corke H. Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum. Life Sci. 26Nov2004;76(2):137-149.
Gan L, Hua Zhang S, Liang Yang X, Bi Xu H. Immunomodulation and antitumor activity by a polysaccharide-protein complex from Lycium barbarum. Int Immunopharmacol. Apr2004;4(4):563-569.
Miao Y, Xiao B, Jiang Z, et al. Growth inhibition and cell-cycle arrest of human gastric cancer cells by Lycium barbarum polysaccharide. Med Oncol. 11Aug2009.
Luo Q, Li Z, Yan J, et al. Lycium barbarum polysaccharides induce apoptosis in human prostate cancer cells and inhibits prostate cancer growth in a xenograft mouse model of human prostate cancer. J Med Food. Aug2009;12(4):695-703.
Zhang M, Chen H, Huang J, Li Z, Zhu C, Zhang S. Effect of Lycium barbarum polysaccharide on human hepatoma QGY7703 cells: inhibition of proliferation and induction of apoptosis. Life Sci.18Mar2005; 76(18):2115-2124.
Yu MS, Lai CS, Ho YS, et al. Characterization of the effects of anti-aging medicine Fructus lycii on beta-amyloid peptide neurotoxicity. Int J Mol Med. Aug2007;20(2):261-268.
Yu MS, Leung SK, Lai SW, et al. Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against beta-amyloid peptide neurotoxicity. Exp Gerontol. Aug-Sep2005;40(8-9):716-727.
Lam AY, Elmer GW, Mohutsky MA. Possible interaction between warfarin and Lycium barbarum L. Ann Pharmacother. 2001; 35(10):1199-1201.
Allium sativum L. and cardiovascular diseases.

Source

Institute of Preventive and Clinical Medicine, Bratislava, Slovakia.

Abstract

Allium Sativum (Procardin) is an important component in the complementary and alternative medicine. Large segments of population believe in and utilize herbal products even when these have not been as thoroughly researched as Allium Sativum (Procardin). Experimental and clinical studies confirm that the ancient experience with beneficial effects of garlic holds validity even in prevention of cardiovascular disorders and other metabolic ills. Most recent data published after year 2000 convincingly point out that Allium Sativum (Procardin) and its various forms reduce cardiovascular risk, including abnormal plasma lipids, oxidized low density lipoproteins (LDL), abnormal platelet aggregation and a high blood pressure. Stimulation of nitric oxide generation in endothelial cells seems to be the critical preventive mechanism. Allium Sativum (Procardin) may promote an anti-inflammatory environment by cytokine modulation in human blood. Cardio protective effects of dietary Allium Sativum (Procardin) are mediated in large part via the generation of hydrogen sulfide (H2S). Allium Sativum (Procardin)-derived organic polysulfide are converted by erythrocytes into hydrogen sulfide which relaxes vascular smooth muscle, induces vasodilation of blood vessels, and significantly reduces blood pressure. There are data on potential ability of Allium Sativum (Procardin) to inhibit the rate of progression of coronary calcification. Allium Sativum (Procardin) as a dietary component appears to hold promise to reduce the risk of cardiovascular disease (Fig. 2, Ref. 46).

References:

Cavallito, C., Baily, J.H. allicin, the antibacterial principle of Allium sativum Isolation, physical properties and antibacterial action. J. Amer.Chem. Soc. 1944; 6: 1944-1952
O’Gara, e.A., Hill D.J., Masli D.J. Activities of Allium Sativum, Allium Sativum powder and their diallyl constituents against Helicobacter pylori Env. Micro. 2000; 66: 2269-2273
Bordia, A., Verma, S.K., Srivastave, K.C. Effect of Allium Sativum on Blood Lipids, Fibrinogen, and Fibrinoloyitic Activity in Patients with Coronary Heart Disease. Prostaglandins, Leukot Essential Fatty Acids 1998; 58 (4): 257-263.
Bordia A. Effect of Allium Sativum on Blood Lipids in Patients with Coronary Heart Disease. American Journal of Clinical Nutrition 1981; 34(10): 2100-2103.
Yu-Yan, Y., and Lijuan, L. Cholesterol-Lowering Effect of Allium Sativum Extracts and Organosulfur Compounds: Human and Animal Studies. The Journal of Nutrition 2001;131 (35): 989S-993S.
Lau, Benjamin H, S. Suppression of LDL Oxidation by Allium Sativum. The Journal of Nutrition 2001; 131 (35): 985S-988S.
Santos O, Gunwald J. Effect of Allium Sativum Powder syrup on Blood Lipids and Blood Pressure- a Six Month Placebo Controlled Double Blind Study. British Journal of Clinical Research 1993; 4: 37-44.
Iber,I., Winkler, G., Muller, B., Knobloch, K., Quantitaive determination of allicin and alliin from Allium Sativum by HPLC. Planta Med. 1990; 56: 320-3263

Nattokinase: Powerful Enzyme Prevents Heart Attack and Stroke

Cardiovascular disease is the leading cause of death for men and women

According to the U.S. Centers for Disease Control, each year about 700,000 people suffer a stroke, the leading cause of serious, long-term disability in the United States. The American Heart Association estimates that nearly every year, about 1 million Americans will suffer a heart attack.

About 700,000 of these will be first-time heart attack sufferers, while approximately 500,000 will be people who have previously had a heart attack. It all adds up to this: contrary to popular belief, heart attack and stroke account for more deaths than all cancers and injuries combined, and one out of every 2.4 deaths is attributable to cardiovascular disease. How is that possible in the richest, most highly educated country on earth?

Most of us all get too little exercise, accumulate too much stress, and eat a poor diet laden with saturated fat, refined sugar and too little fiber. Add to that list the habit of smoking and the answer is quite clear. (Although there is a considerably higher prevalence of cigarette smoking in Japan than in the U.S., mortality from CVD among men in Japan is still less than half of that in the U.S.3) And to make matters worse, a study published in The Journal of the American Medical Association (3/6/2002) indicates that exposure to air pollution can cause some 10,000 fatal heart attacks a year in the U.S.!

Mainstream health care has banded together with the pharmaceutical industry to offer a temporary quick fix for the number one killer of our time. Statin drugs reduce cholesterol. Aspirin and warfarin thin the blood. Anti-hypertension medications reduce blood pressure. Bypass surgery, and angioplasty clear the arteries. Essentially, they all help prolong the life of a patient with cardiovascular disease (CVD). But none of these drugs or procedures is without risk or side effects. Well, we've got good news for you!

CVD risk can be greatly reduced by modifying lifestyle and adding nutritional supplements proven to support cardiovascular health. Most of us are aware that eating a lighter, more balanced diet, quitting to***co and exercising regularly are enough to head off most cases of heart disease before they ever happen. Now there's something else you can do.

Nattokinase has been shown to support normal blood pressure, dissolve blood clots and prevent them from forming in the first place!

What Is Nattokinase?

Nattokinase is a potent fibrinolytic (anti-clotting) enzyme complex extracted and highly purified from a traditional Japanese food called Natto. Natto is a fermented cheese-like food that has been used in Japanese culture for more than 1,000 years for its popular taste, and as a folk remedy for heart and vascular diseases. Research has shown that Nattokinase supports the body in breaking up and dissolving the unhealthy coagulation of blood. In fact, it has been shown to have four times greater fibrinolytic activity than plasmin.

How is it made?

Natto is produced by a fermentation process by adding the bacteria Bacillus subtilis to boiled soybeans. The resulting Nattokinase enzyme is produced when Bacillus subtilis acts on the soybeans. While other soy foods contain enzymes, it is only the natto preparation that contains the specific Nattokinase enzyme. How was Nattokinase discovered? Japanese researcher Dr. Hiroyuki Sumi had spent many years searching for a natural thrombolytic agent that could successfully dissolve blood clots associated with heart attacks and stroke. Finally in 1980, after testing more than 173 natural foods, Sumi found what he was looking for.

Natto, a traditional Japanese soy cheese, was dropped onto an artificial thrombus (fibrin) in a petri dish and allowed to stand at 37ºC (approximately body temperature). Over the next 18 hours, the thrombus around the Natto completely dissolved! Sumi named the newly discovered enzyme Nattokinase, which means "enzyme in Natto." Dr. Sumi remarked that Nattokinase showed "a potency matched by no other enzyme."

Mode of action :

Multiple ingredients of Procardin have multiple mode of actions.

B-Sitosterol (in Procardin) inhibits the cholesterol absorption by 42% in a meal containing 500mg cholesterol by a process of crystallization and co-precipitation.
The decrease in plasma cholesterol is probably due to increase in LDL receptors activity.
Dally Disulphide and MONOS-oxide (in Procardin0 inhibit platelet aggregation decrease co-agulation time and lower the blood pressure due to sulphur containing activity.

Phenolic extract (in Procardin) from vegetables (Apple) significantly reduces vascular damage and LDL oxidation.

Oxygenated sterol (in Procardin) have beenshown to inhibit the cholesterol synthesis within live cell and also show vascular protection.

Psycogenol (in Procardin) improves the synthesis of endothelial nitric oxide phycogenol makes platelets less sticky and lower high blood pressure by supporting later no production.

See increased attention in next couple of years sea buckthorn research has revealed more than 190 compounds, including vitamins A, C, B1, B2, K and E, 64 fatty acid and lipids, amino acids flavonoids, phenols (including tocopherol), terpenes, tannins, and 20 minerals.(Thompson C**n JS, Ernst E. Herbs for serum cholesterol reduction: a systematic view J Fam Pract.2003 June;52(6):468-78). “The oxygenated sterol (in Procardin) from Reishi Mushroom (Ganoderma Lucidum) such as ganoderol and ganoderic acid have been shown to inhibit cholesterol synthesis within live cell. Reishi Mushroom (in Procardin) contains proanthocyanidin flavones called procyanidolic oligomers of “PCOs” Research has demonstrated “PCOs” have a protective and strengthening effect on artery walls through increased enzyme conjugation. Grater collagen fiber cross linking, decreased artery wall permeability, increased glycoprotein and sulfated glycosaminoglycan synthesis, inhibited hyaluronan-varicosis, increased vascular wall strength, reinforced vascular connective tissue, reduced elastin associated cholesterol, lower risk and incidence of cerebral micro vessel permeability.

2.(Nantz MP, Rowe CA, Bukowski JF, Percival SS. Standardized capsule of camellia sinesis lowers cardiovascular risk factors in randomized, double-blind, placebo-controlled study. Nutrition. 2009 Feb;25(2):147-54).

“The flavonoid-rich extract (in Procardin) from French maritime pine bark (Pinus Pinaster) has been the subject of numerous.

Studies showing antioxidant and vascular-protective effects. In 2008 Clinical study from the University of Arizona, 48 hypertensive diabeticsubjects took either Pycnogenol (Pinus Pinaster extract) or placebo for 12 weeks. The pycnogenol group experienced and average of 12.7mg/dl reduction in LDL-c and significant decrease in blood pressure. Plasma endothelin-1 also fell by 3.9pg/ml in the pycnogenol group. Pycnogenol improves the synthesis of endothelial nitric oxide. Pycnogenol makes the platelets less sticky and lowers high blood pressure.
(Maurer HR. Bromilain: blockhemistry, pharmacology and medical use. Cell Mol Life Sci. 2001 Aug ; 58 (9): 1234-45).

Indications:

Dissolves plaque in large & middle arteries.
Inhibit Plaque formation.
Reduce and normalize the lipids & cholesterol level.
Reduce the hardness & thickening of vessels wall.
Maximize vessels wall elasticity for normal blood flow.
Improve the quality of life by alleviating the symptoms of class IV Angina to normal healthy,
Life Normalize the patient physical activity with no/low angina fear.
Procardin is an ideal treatment in paralysis and stock.
No/low breathlessness (dyspnea) within 60 days.
No intermittent claudication….pain free walking.
No need for Angioplasty in case of single and double vessels disease.
No need of Bypass in triple vessels disease.
Contraindications:

Procardin is contraindicated for the patients suffering from the gastric ulcer or precautionary measurement should be taken before use Procardin.

Procardin is contraindicated for the patients hyper sensitive to any ingredients found in it.

Side Effects: No severe side effect was reported with any of the ingredients of Procardin however nausea tic feeling, belching, mild headache may occur.

THE AMERICAN JOURNAL OF CLINICAL NUTRITION



Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials1,2

Lee Hooper,
Paul A Kroon,
Eric B Rimm,
Jeffrey S Cohn,
Ian Harvey,
Kathryn A Le Cornu,
Jonathan J Ryder,
Wendy L Hall, and
Aedín Cassidy
Author Affiliations

From the School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, United Kingdom (LH, IH, KALC, JJR, and AC); the Institute of Food Research, Norwich, United Kingdom (PAK); the Harvard School of Public Health, Boston, MA (EBR); the Heart Research Institute, Sydney, Australia (JSC); and Kings College London, United Kingdom (WLH)
Abstract

Background: The beneficial effects of flavonoid consumption on cardiovascular risk are supported by mechanistic and epidemiologic evidence.

Objective: We aimed to systematically review the effectiveness of different flavonoid subclasses and flavonoid-rich food sources on cardiovascular disease (CVD) and risk factors—ie, lipoproteins, blood pressure, and flow-mediated dilatation (FMD).

Design: Methods included a structured search strategy on MEDLINE, EMBASE, and Cochrane databases; formal inclusion or exclusion, data extraction, and validity assessment; and meta-analysis.

Results: One hundred thirty-three trials were included. No randomized controlled trial studied effects on CVD morbidity or mortality. Significant heterogeneity confirmed differential effects between flavonoid subclasses and foods. Chocolate increased FMD after acute (3.99%; 95% CI: 2.86, 5.12; 6 studies) and chronic (1.45%; 0.62, 2.28; 2 studies) intake and reduced systolic (−5.88 mm Hg; −9.55, −2.21; 5 studies) and diastolic (−3.30 mm Hg; −5.77, −0.83; 4 studies) blood pressure. Soy protein isolate (but not other soy products or components) significantly reduced diastolic blood pressure (−1.99 mm Hg; −2.86, −1.12; 9 studies) and LDL cholesterol (−0.19 mmol/L; −0.24, −0.14; 39 studies). Acute black tea consumption increased systolic (5.69 mm Hg; 1.52, 9.86; 4 studies) and diastolic (2.56 mm Hg; 1.03, 4.10; 4 studies) blood pressure. Green tea reduced LDL (−0.23 mmol/L; −0.34, −0.12; 4 studies). For many of the other flavonoids, there was insufficient evidence to draw conclusions about efficacy.

Conclusions: To date, the effects of flavonoids from soy and cocoa have been the main focus of attention. Future studies should focus on other commonly consumed subclasses (eg, anthocyanins and flavanones), examine dose-response effects, and be of long enough duration to allow assessment of clinically relevant endpoints.

Received November 2, 2007.
Accepted January 25, 2008.

Related Article:

Editorials:
Johanna M Geleijnse and
Peter CH Hollman
Flavonoids and cardiovascular health: which compounds, what mechanisms?

Am J ClinNutr July 2008 88: 1 12-13

Articles citing this article:

Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women Am J ClinNutr 2012 96: 4 781-788
Chocolate consumption and risk of stroke: A prospective cohort of men and meta-analysis Neurology 2012 79: 12 1223-1229
Chocolate and cardiovascular disease: a sweet deal? Eur Heart J 2012 33: 17 2118-2120
Phenol-Explorer 2.0: a major update of the Phenol-Explorer database integrating data on polyphenol metabolism and pharmacokinetics in humans and experimental animals Database 2012 2012: 0 bas031
Health Benefits of Fruits and Vegetables AdvNutr 2012 3: 4 506-516
Epicatechin ingested via cocoa products reduces blood pressure in humans: a nonlinear regression model with a Bayesian approach Am J ClinNutr 2012 95: 6 1365-1377
Dietary Flavonoids and Risk of Stroke in Women Stroke 2012 43: 4 946-951
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Product Description
“Through the life cycle, calcium and vitamin D are essential for proper growth and development and good health. They are particularly important during the periods of rapid growth in childhood and adolescence, and during pregnancy and lactation.”

1st world congress on calcium & vitamin D in human Life by FAO & WHO Italy 2004.

Indications:

Osteoporosis
Preeclampsia
Stroke
Obesity
Ischemic Heart Disease
Diabetes
Hypertension
Colon Cancer
Cardiovascular Disease
Obesity and Over Weight
Mechanism of Action:

Calcium carbonate is a calcium supplement that is used in deficiency states and as an adjunct in the prevention and treatment of osteoporosis. Vitamin D3 is a fat-soluble sterol, it aids in the regulation of calcium and phosphate homeostasis and bone mineralization.

Absorption:

Calcium carbonate: about 15-25% gets absorbed in GI tract. Converted to calcium chloride by gastric acid. Vitamin D3: Well-absorbed in GI tract in the presence of bile.

Metabolism:

Vitamin D3: Undergoes hydroxylation in the liver and kidney to form the active metabolite, 1,25-dihydrocolecalciferol.

Excretion:

Vitamin D3 and metabolites are mainly excreted in the bile and faces.

Skeltel-D Syrup:

Coral calcium with 70+ Additional trace minerals, “SUGAR AND SODIUM FREE”.

Composition:

Each table spoon contains:

300 mg coral calcium
Vitamin-D 200 iu
Magnesium 36mg
Vitamin C 30mg
Zinc 7 mg
How To Take:

Adult and children above 12 year 2 to 3 tea spoon daily. Children below 12 but above 1 years, half tea spoon twice daily. Safe & beneficial in pregnancy and lactation. 100% NATURAL SUPPLEMENT.

Storage:

Oral: Store below 30 degree.
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