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This popular blend has provided relief to many people and sharing it today with someone made me think it's time to repost it.

Approximately 12% of the population (children and adults) experience painful and debilitating migraines. Migraines are complex and their exact cause and trigger are not known. Inflammation in the nervous system (neurogenic inflammation), dilation of blood vessels on the surface of the brain, and alterations in neurochemicals and neuropeptides (serotonin, nitric oxide, endothelin, CGRP) are some of the abnormal brain activities associated with migraines.

A recent review article concluded that lavender, peppermint, German chamomile, anise, basil CT estragole, rose, and garlic essential oils were useful for migraines. They further identified constituents in these oils that contribute to relief of factors that contribute to migraines: menthol (pain relief, reduces neurogenic inflammation); borneol (relaxes blood vessels, reduces neurogenic inflammation); 1,8-cineole (dilates blood vessels, reduces neurogenic inflammation, inhibits CNS pain); linalool/linalyl acetate (reduces neurogenic inflammation, inhibits CNS pain); menthone (reduces neurogenic inflammation); limonene (pain relief, reduces neurogenic inflammation, balances vasomotor abnormalities); alpha-pinene (reduces neurogenic inflammation); beta-elemene (reduces neurogenic inflammation); beta-caryophyllene (reduces neurogenic inflammation, balances vasomotor abnormalities); trans-anethole (reduces neurogenic inflammation, balances vasomotor abnormalities); diallyl trisulfide (reduces neurogenic inflammation); estragole (reduces neurogenic inflammation, balances vasomotor abnormalities); and citronellol (relaxes blood vessels, reduces neurogenic inflammation, reduces excess pain response).
https://www.sciencedirect.com/science/article/pii/S0378874120332086

Based on the oils and the mechanisms by which the constituents work, create a blend in a 10 mL roller bottle using the oils in the image.

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Fatigue is a term used to describe an overall lack of energy or feeling of tiredness. Many people today reach for energy drinks or shots loaded with caffeine to avoid fatigue. However, this may make things worse in the long run and actually contribute to your fatigue.

First off, about 10% of humans don't clear caffeine from the body efficiently due to polymorphisms in the CYP1A2 gene, which controls the expression of enzymes that breakdown and clear caffeine. Genetics aside, consumption of caffeine triggers the release of cortisol. High caffeine levels can negatively effect cortisol and energy levels. Too much caffeine can even overwork your adrenals (to produce cortisol excessively) and make them work less efficiently. Additionally, caffeine increases short-term energy and alertness at the expense of the long term. Caffeine interferes with the activity of adenosine, which is a neurotransmitter that puts the brakes on other neurotransmitters that trigger excitation and stimulation. At some point, caffeine is overcome by adenosine (they bind to the same receptors) and a crash or slump occurs.

A more natural solution for fatigue may be peppermint essential oil. A review article reported that menthol in peppermint may increase cellular energy metabolism by stimulating the central nervous system. Specifically, menthol stimulates the adrenal cortex to enhance energy. In addition, clinical research shows that peppermint increases alertness and improves mental freshness.
https://pubmed.ncbi.nlm.nih.gov/35994817/

Inhale peppermint when feeling fatigued or place one drop on your tongue to promote alertness and mental freshness.